DMAE has been used in connection with the following conditions (refer to the individual health concern for complete information):
|Science Ratings||Health Concerns|
Reliable and relatively consistent scientific data showing a substantial health benefit.
Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.
Clinical studies of DMAE have used up to 1,600 mg per day with no reports of side effects.1 For this reason, DMAE is believed to be relatively nontoxic. However, one study using higher intakes for Alzheimer’s disease patients did report symptoms of drowsiness and confusion with the use of DMAE.2 A possible side effect of lucid dreaming (in which the dreamer is conscious and in control of a dream) is suggested with DMAE use.3 Depression and hypomania (moderate symptoms of mania) have been reported as side effects of DMAE.4
At the time of writing, there were no well-known drug interactions with DMAE.
1. Casey DE, Denney D. Dimethylaminoethanol in tardive dyskinesia. N Engl J Med 1974;291:797.
2. Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer’s disease. Am J Psychiatry 1981;138:970–2.
3. Sergio W. Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams. Med Hypotheses 1988;26:255–7.
4. Casey DE. Mood alterations during deanol therapy. Psychopharmacology 1979;62:187–91.
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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires September 2008.